Services


Special Tests
 
Oncovantage
 
 
TEST: OncoVantage
 
OTHER TEST REQUEST NAME:
Not applicable
 
TEST COMPOSITION:
Genes tested:
1. AKT1
2. ALK
3. BRAF
4. CTNNB1
5. DDR2
6. EGFR
7. ERBB2
8. ERBB4
9. FBXW7
10. FGFR2
11. FGFR3
12. FGFR4
13. FOXL2
14. GNA11
15. GNAQ
16. GNAS
17. HRAS
18. IDH2
19. KIT
20. KRAS
21. MAP2K1
22. MET
23. NOTCH 1
24. NRAS
25. PDGFRA
26. PIK3CA
27. PIK3R1
28. PTCH1
29. PTEN
30. RET
31. SMO
32. STK11
33. TP53
 
INTENDED USE:
This multiplex panel will allow physicians to choose the most appropriate therapy for their patients based on the alterations found in the individual's tumor sample DNA.
Guidelines exist for using results from many of these genes for selection of FDA approved
therapies. By testing for other genes the physician can become aware of alternative
treatments available to the patient based on presence of mutations in other genes
the physicians might not have considered
Additional genes indicate prognosis of those patients with mutations, thus allowing physicians and patients to choose more or less aggressive therapies
 
METHODOLOGY:
Next Generation Sequencing (NGS)/Ion Torrent Personal Genome Machine
 
LABORATORY SECTION:
Special Test
 
SPECIAL INSTRUCTIONS/PATIENT PREPARATIONS:
• No patient preparation necessary.
• Inform laboratory prior to receiving of sample.
 
COLLECTION/SAMPLE CONTAINER:
Slide holders or mailers for microscope slides; FFPE tissue blocks can either be wrapped in paper or placed in a box.
 
SPECIMEN AND VOLUME REQUIREMENT
Note: Follow tube manufacturer recommendation. :
Formalin-fixed paraffin-embedded (FFPE) tissue block
1 H&E stained slide representative of the submitted tissue block.
Histopathology report for the submitted tissue block
 
ALTERNATIVE SPECIMEN AND VOLUME REQUIREMENT:
Not Applicable
 
SPECIMEN STABILITY
•   ROOM TEMPERATURE (15-25°C) : Indefinite
•   REFRIGERATED TEMPERATURE (2-8°C) : Not applicable
•   FREEZER TEMPERATURE (-20°C) : Not applicable
 
TRANSPORT TEMPERATURE:
Transport specimen at 15°C ~25 °C (room temperature)
 
REJECTION CRITERIA:
• Incomplete information in the Request Form
• Improper or insufficient labeling of tissue blocks or slides
• Inadequate tissue available on the tissue block
 
RUNNING DAY:
Batch Running
 
CUT OFF TIME:
Friday 4:00 PM
 
TAT/RELEASING OF RESULTS:
21 days (excluding Saturdays, Sundays and Holidays)
 
REFERENCE INTERVAL/RESULT INTERPRETATION:
Not Applicable
 
LIMITATIONS/INTERFERENCES:
None specified.
 
FREQUENTLY ASKED QUESTIONS (FAQS):
Not applicable

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