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Special Tests
 
Neuromyelitis Optica
Autoantibody Test (Anti-NMO)
 
TEST: Anti-Neuromyelitis Optica Test
 
OTHER TEST REQUEST NAME:
Anti-NMO
Anti-Aquaporin 4
Anti-AQP4 antibodies
Devic’s Disease or Syndrome
Opticospinal Encephalomyelitis
 
TEST COMPOSITION:
Not Applicable
 
INTENDED USE:
Aids in the qualitative in vitro determination of human autoantibodies against aquaporin-4.
Useful in the diagnosis of neuromyelitis optica which is an inflammatory, demyelinating disease of the central nervous system that selectively affects the optic nerve and at the same time or a few months later the spinal cord.
 
METHODOLOGY:
Indirect Immunofluorescence Test
 
LABORATORY SECTION:
Molecular  Diagnostics Section
 
SPECIAL INSTRUCTIONS/PATIENT PREPARATIONS:
No patient preparation required
 
COLLECTION/SAMPLE CONTAINER:
EDTA (Purple Top)
 
SPECIMEN AND VOLUME REQUIREMENT
Note: Follow tube manufacturer recommendation.:
2 - 3 mL Plasma
 
ALTERNATIVE SPECIMEN AND VOLUME REQUIREMENT:
2 - 3 mL Serum
2 mL CSF
SPECIMEN STABILITY
Plasma/Serum Samples
 
Refrigerated Temperature (2 to 8 'C) ; 14 days
Room Temperature (15 to 25'C); Not specified
Freezer Temperature (-20'C) : Not specified
             CSF Sample
 
Refrigerated Temperature (2 to 8'C): 14 days
Room Temperature (15 to 25'C): Not specified
Freezer Temperature (-20): Not specified
•   ROOM TEMPERATURE (15-25°C) : Not Applicable
•   REFRIGERATED TEMPERATURE (2-8°C) : Not Applicable
•   FREEZER TEMPERATURE (-20°C) : Not Applicable
TRANSPORT TEMPERATURE :
Transport specimen at 2 to 8'C (with cold packs)
 
REJECTION CRITERIA:
Imprperly labeld specimens
Quantity not sufficient
Specimen stored exceeded outside required stability
Incorrect use of container
 
RUNNING DAY:
Wednesday
 
CUT OFF TIME:
Tuesday, 8:00PM
 
TAT/RELEASING OF RESULTS:
Thursday, 2:00PM
 
REFERENCE INTERVAL/RESULT INTERPRETATION:
POSITIVE
 
- Indication of NMO or NMO spectrum diseases
 
NEGATIVE
 
- No antibodies against AQP-4 detected in the patient sample
 
LIMITATIONS/INTERFERENCES :
None identified
 
FREQUENTLY ASKED QUESTIONS (FAQS):
Not Applicable

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